Causes of GIST

By 23/01/2019 May 20th, 2020 No Comments


A risk factor is anything that increases a person’s chance of developing a tumor. Although risk factors can influence the development of a tumor, most do not directly cause the disease. Some people with several risk factors never develop a tumor, while others with no known risk factors do.

The majority of GISTs develop for no known reason, called sporadic. There are no known environmental or behavioural risk factors contributing to GIST. Therefore, patients should not worry that their diet or lifestyle choices contributed to GIST.

Random genetic mutations are the apparent cause of GISTs. The majority of GISTs show identified mutations in cell-surface proteins called tyrosine kinase receptors. Most GISTs show mutations in a gene that produces a growth factor receptor called KIT.

However, there are rare examples of GIST running in families due to an inheritable germline mutation. In addition, people affected by neurofibromatosis type 1 (NF1) have an increased chance of developing GIST.

Dr. Deepak Chhabra

Dr. Deepak Chhabra

Dr. Deepak Chhabra is a consultant Surgical Oncologist with an extensive experience in cancer surgeries. After completing his Masters in Surgery (from the prestigious T.N.Medical College and B.Y.L Nair Hospital in Mumbai) and Diplomat from the National Board of Examinations, he subsequently received his specialist oncosurgical training at Mumbai.

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